1. Journal of Prosthetic Dentistry

J Prosthet Dent.2014 Jan;111(1):16-9. doi: 10.1016/j.prosdent.2013.07.009. Epub 2013 Nov 5.

Metal-reinforced single implant mandibular overdenture retained by an attachment: a clinical report.

Grageda E1, Rieck B2.

Author information

Associate Professor, Department of Prosthodontics, National Autonomous University of Mexico UNAM and Medica Sur Hospital; and Private practice, Mexico City, Mexico. Electronic address: [email protected].

Owner, Dental Technik Laboratory, National Autonomous University of Mexico UNAM; Medica Sur Hospital, Mexico City, Mexico.


Results of studies have shown that a single implant mandibular overdenture significantly increases the satisfaction and quality of life of patients with edentulism.

The single implant-retained overdenture has the additional advantage of being less expensive and invasive than a 2-implant supported overdenture but has a high incidence of fracture of the acrylic resin base at the point of the implant.

The treatment, design, and fabrication of a metal-reinforced single-implant mandibular overdenture with the Locator attachment as a retention device is described.

Copyright © 2014 Editorial Council for the Journal of Prosthetic Dentistry. Published by Mosby, Inc. All rights reserved.



[PubMed – in process]



2. Dentistry Today

Dent Today.2007 Apr;26(4):130, 132-5; quiz 135.

Achieving an aesthetic anterior-posterior rotational path partial denture: case report.

Grageda E.

Author information

Universidad Nacional Autonoma de Mexico. [email protected]


[PubMed – indexed for MEDLINE]



3. Journal of California Dental Association

J Calif Dent Assoc.2005 Dec;33(12):951-9.

Celebrex offers a small protection from root resorption associated with orthodontic movement.

Jerome J, Brunson T, Takeoka G, Foster C, Moon HB, Grageda E, Zeichner-David M.


Tooth movement results from alveolar bone resorption/deposition following application of orthodontic forces, and root resorption can be an undesirable complication associated with this process.

No treatment for external root resorption is available to date.


To determine if COX-2 inhibitors like Celebrex are effective in protecting root resorption associated with orthodontic forces.


A force of 80 grams was applied to the left maxillary first molars of 7-week-old female Wistar rats using nickel titanium closed coil springs attached to the cervical area of the incisors with 0.010 stainless-steel ligature wires.

Twenty animals were divided into three experimental groups: one receiving no treatment, the second receiving 25mg/kg, and the third receiving 50 mg/kg of celecoxib (Celebrex) in their drinking water.

Rats were maintained on a soft diet and euthanized two weeks after initial placement of the force. Paraffin-embedded sections of the right (control) and left (experimental) maxillae were stained with H&E and the areas of root resorption were examined by counting the number of lacunaes in the roots.


No difference in the distance of tooth movement (0.5 mm/two weeks) was seen in all three groups.

The rats that received the low dose of Celebrex showed no statistically significant difference in root resorption than that of the rats that received no dose.

The rats that received the high dose of Celebrex showed a lower number of lacunaes (mean = 3.5) than that of the control group (mean 10.2; p=0.02).


Administration of Celebrex during the application of orthodontic forces does not interfere with tooth movement and appears to offer some slight protection against root resorption.



[PubMed – indexed for MEDLINE]



4. Journal of Prosthetic Dentistry

J Prosthet Dent.2006 Jan;95(1):84-5.

Fabrication of a maintenance template for fixed complete denture.

Grageda E, Thammasithiboon P.

Author information

Dental School, University of Texas Health Science Center at San Antonio, 78229, USA. [email protected]



[PubMed – indexed for MEDLINE]



5. Journal of Biomedical Materials Research

J Biomed Mater Res A.2005 Aug 1;74(2):247-53.

A novel osteotropic biomaterial OG-PLG: in vitro efficacy.

Whang K, Grageda E, Khan A, McDonald J, Lawton M, Satsangi N.

Author information

Department of Restorative Dentistry, Division of Biomaterials, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MSC 7890, San Antonio, TX 78229-3900, USA.


Previously, a novel osteotropic biomaterial, OG-PLG [simvastatin grafted to poly(lactide-co-glycolide), PLG], was synthesized and shown to have degradation-controlled release kinetics.

The objective here was to determine the effect of grafting statins to PLG on bone regeneration in vitro.

Rat bone marrow cells were stimulated in vitro with simvastatin dissolved in media, saponified simvastatin dissolved in media, simvastatin released through diffusion from emulsion freeze-dried scaffolds, and OG-PLG. Unstimulated cultures and cultures stimulated with dexamethasone were used as negative and positive controls, respectively. In vitro bone formation was assessed using the alkaline phosphatase (ALP) and von Kossa assays at different times up to 16 days.

ALP analysis revealed that saponified simvastatin at 10(-7)M and OG-PLG significantly increased ALP expression at various time points.

von Kossa assay showed that simvastatin, saponified simvastatin, and OG-PLG significantly enhanced mineralization, with the effect from OG-PLG being the most significant.

In short, OG-PLG significantly enhanced in vitro bone cell mineralization beyond the effect of simvastatin or saponified simvastatin dissolved in media and simvastatin released via diffusion from scaffolds.

(c) 2005 Wiley Periodicals, Inc.



[PubMed – indexed for MEDLINE]



6. Journal of Oral Implantology

J Oral Implantol.2005;31(1):2-17.

Bone formation in the maxillary sinus by using platelet-rich plasma: an experimental study in sheep.

Grageda E, Lozada JL, Boyne PJ, Caplanis N, McMillan PJ.

Author information

Advanced Education Program in Implant Dentistry, Loma Linda University, Loma Linda, California, USA.[email protected]


Recently, platelet-rich plasma (PRP) has been proven to be an effective regeneration adjunct when combined with autogenous bone in the reconstruction of mandibular defects. However, little is known about the effect of PRP when combined with a bone allograft in the maxillary sinus.

The purpose of this study was to quantitatively evaluate the ability of PRP to enhance bone regeneration in the maxillary sinus of sheep when combined with demineralized freeze-dried bone allograft (DFDBA) and cortical cancellous freeze-dried bone allograft (CCFDBA). Ten sheep were selected for bilateral sinus augmentation DFDBA + CCFDBA + PRP (test) and DFDBA + CCFDBA (control).

Five were sacrificed at 3 months and the other 5 at 6 months.

Hematology tests were performed for platelet count, and histology slides were obtained for histomorphometric analysis taking 2 measures of interest: total area (square millimeters) and percentage of bone fill. Student t tests showed no significant difference between test and control groups for total area (P > .25) and percentage of bone fill (P > .80) at either 3 or 6 months.

The control group showed no statistical difference for total area (P < .095) and percentage of bone fill (P <.60) between 3- and 6-month healing times.

The test group, however, showed a significant increase in total area (P <.025) but not in percentage of bone fill (P <.40) for the 2 healing periods.

When the treatments were compared for interactions within the animal model, no clear tendency was evident for the test group to perform in relation to the control group regarding total area (r = .766, P < .01).

A moderate tendency existed between the percentages of bone filled (r = .824, P < .005). Platelet-rich plasma showed higher platelet count than did the whole blood (2 to 5 times). However, no correlation was found between the log ratio and the bone measures.

Within the limitations of this study, PRP failed to enhance or accelerate bone regeneration in the maxillary sinus of sheep when combined with bone allograft.



[PubMed – indexed for MEDLINE]



7.  Implant Dentistry

Implant Dent.2004 Dec;13(4):301-9.

Platelet-rich plasma and bone graft materials: a review and a standardized research protocol.

Grageda E.

Author information

Department of Prosthodontics, The University of Texas Health Science Center at San Antonio, TX 78229, USA.[email protected]


Since the introduction of platelet-rich plasma (PRP), several authors (clinicians and researchers) have investigated its efficacy using different bone grafting materials.

There have been various research protocols and different types of clinical cases.

This position paper suggests a standardized research protocol for the use of, and evaluation of PRP and bone grafts.



[PubMed – indexed for MEDLINE]



8. Journal of Dental Research  March 1999 78: 105-556, doi:10.1177/0022034599078S101

Gene expression Induced by orthodontics forces and root resorption,

Grageda, E., Zeichner David, M., Bringas P. Reyna, J., Yacaman, F. Journal of Dental Research 1999: 78 Special Issue. 775.

Link :


9. Journal of  Dental Research March 2001 80: 527-797, doi:10.1177/0022034501080S106

Cytokine expression as a consequence of orthodontic tooth movement and/or root resorption

Reyna, J., Grageda, E., Moon, H., Yacaman, F., Zeichner David,M.



10. Capítulo de libro. Biolological Mechanisms of Tooth Eruption, Resorption and Movement. Edited by Davidovitch, Z., Mah, J. An Suthanarak, S. (2006) Harvard Society for the Advancement of Orthodontics. Boston USA.

Gene expression induced by orthodontic tooth movement and/or root resorption

Reyna, J., Moon, H., Maung, V., Panahpour, M., Achberger, R., Grageda, E., Bringas, P., Zeichner- David, M



11. Google books. Gene Expression Induced by Orthodontic Forces and Root Resorption. Edited by: University of Southern California, 1999 – 74 pages

Enrique Grageda

Enrique Grageda


Mah, H., Grageda, E., Advances in imaging for orthodontic practice. Orthodontic Products. June 1999, 26-28